Scholar Rock Holding Corporation

Scholar Rock Holding Corporation a biopharmaceutical company focuses on the discovery and development of medicines for the treatment of serious diseases in which signaling by protein growth factors plays a fundamental role. The company develops Apitegromab an inhibitor of the activation of latent myostatin that has completed the Phase 3 clinical trials for the treatment of spinal muscular atrophy; and SRK-181 which is in Phase 1 clinical trials for the treatment of cancers that are resistant to checkpoint inhibitor therapies such as anti-PD-1 or anti-PD-L1 antibody therapies. It is also developing a pipeline of novel product candidates with potential to transform the lives of patients suffering from a range of serious diseases including neuromuscular disorders cancer fibrosis and iron-restricted anemia. The company has a collaboration agreement with Gilead Sciences Inc. to discover and develop specific inhibitors of transforming growth factor beta activation for the treatment of fibrotic diseases. Scholar Rock Holding Corporation was founded in 2012 and is headquartered in Cambridge Massachusetts.