Agenus Inc

Agenus Inc. a clinical-stage immuno-oncology company discovers and develops immuno-oncology products in the United States and internationally. The company offers Retrocyte Display an antibody expression platform for the identification of fully human and humanized monoclonal antibodies; and display technologies. It develops QS-21 Stimulon adjuvant a saponin-based vaccine adjuvant. The company also develops Balstilimab an anti-PD-1 antagonist that has completed Phase II clinical trial to treat second line cervical cancer; AGEN1181 an anti-CTLA-4 monospecific antibody that is in Phase 2 clinical trial; AGEN2373 a CD137 monospecific antibody that is in Phase 1b clinical trial; AGEN1423 a tumor microenvironment conditioning anti-CD73/TGFß TRAP bi-functional antibody that has completed Phase 1 clinical trial; AGEN1571 an ILT2 monospecific antibody that is in Phase 1 clinical trial; BMS-986442 a TIGIT bispecific antibodies; and AGEN1327 a human monoclonal antibody. In addition it develops INCAGN1876 a GITR monospecific antibody; INCAGN2390 a TIM-3 monospecific antibody; INCAGN2385 a LAG-3 monospecific antibody; MK-4830 a monospecific antibody targeting ILT4; UGN-301 a zalifrelimab intravesical solution for the treatment of cancers of the urinary tract that is in a Phase 1 clinical trial; AGENT 797 an iNKT cells that is in Phase 1 clinical trial for solid tumors multiple myeloma and viral ARDS; and AGEN1884 a first-generation anti-CTLA-4 monospecific antibody. The company operates under Agenus MiNK Prophage Retrocyte Display and Stimulon trademarks. It has collaborations with Bristol-Myers Squibb Company Betta Pharmaceuticals Co. Ltd. Incyte Corporation Merck Sharpe & Dohme and Gilead Sciences Inc. The company was formerly known as Antigenics Inc. and changed its name to Agenus Inc. in January 2011. Agenus Inc. was founded in 1994 and is headquartered in Lexington Massachusetts.